Inclusion and release of hinokitiol into/from MCT-β-CD fixed on Japanese washi paper

The potential for surface modification of paper by modified cyclodextrins was demonstrated by the model system of Japanese washi paper and monochlorotriazinyl-beta-cyclodextrin (MCT-beta-CD). MCT-beta-CD was covalently bonded to the paper. The optimal bonded reaction conditions were found to be 10 min at 150 degrees C with a moisture content of less than 2.5 (g water/g dry paper). The bounded MCT-beta-CD on the paper was able to include and release hinokitiol representing the group of antibacterial agents. The maximum molar inclusion ratio of hinokitiol in the immobilized MCT-beta-CD was around 0.8. The release rates of hinokitiol, included in the fixed MCT-beta-CD, were monitored at 50 degrees C for different relative humidities. The release rate was strongly influenced by the relative humidity. These results demonstrate that the antibacterial agent can be included and released from MCT-beta-CD fixed on the paper. The antibacterial activity of the fixed hinokitiol against airborne microorganisms was demonstrated.