The Prins cyclization reaction: An efficient stractegy for the stereoselective synthesis of substituted tetrahydropyran rings.

被引：15
作者：
Vasconcellos, Mario Luiz A. A.
Miranda, Leandro S. M.
机构：
[1] Univ Fed Paraiba, Dept Quim, BR-58059900 Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, BR-21941590 Rio De Janeiro, Brazil
来源：
QUIMICA NOVA | 2006年 / 29卷 / 04期
关键词：
Prins cyclization; tetralrydropyrans; stereoselective synthesis;
D O I：
10.1590/S0100-40422006000400035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Prins cyclization reaction has significantly advanced in the last years as demonstrated by a number of applications described in the literature. The objective of this report is to introduce this powerful synthetic methodology to the undergraduate and graduated student. since it is rarely presented in an organic synthesis formal course. This reaction is, in some cases, the methodology of choice for the preparation of natural products or drugs that present the tetrahydropyrane moiety in their structures. In this' report we show some aspects of this reaction, including mechanism, scope and limitations.
引用
收藏
页码：834 / 839
页数：6
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