Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

被引：30

作者：

Blass, Benjamin E. ^{[1
]}

Coburn, Keith ^{[1
]}

Lee, Wenlin ^{[1
]}

Fairweather, Nell ^{[1
]}

Fluxe, Andrew ^{[1
]}

Wu, Shengde ^{[1
]}

Janusz, John M. ^{[1
]}

Murawsky, Michael ^{[1
]}

Fadayel, Gina M. ^{[1
]}

Fang, Bin ^{[1
]}

Hare, Michelle ^{[1
]}

Ridgeway, Jim ^{[1
]}

White, Ron ^{[1
]}

Jackson, Chris ^{[1
]}

Djandjighian, Laurent ^{[1
]}

Hedges, Richard ^{[1
]}

Wireko, Fred C. ^{[1
]}

Ritter, Amanda L. ^{[1
]}

机构：

[1] Procter & Gamble Co, Hlth Care Res Ctr, Mason, OH 43040 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期

关键词：

atrial fibrillation; Kv1.5 ion channel; 1,2,3-triazole;

D O I：

10.1016/j.bmcl.2006.06.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4629 / 4632

页数：4

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