Mapping Robust Genetic Variants Associated with Exercise Responses

被引：15

作者：

Alvarez-Romero, Javier ^{[1
]}

Voisin, Sarah ^{[1
]}

Eynon, Nir ^{[1
,2
]}

Hiam, Danielle ^{[1
]}

机构：

[1] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia

[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia

来源：

INTERNATIONAL JOURNAL OF SPORTS MEDICINE | 2021年 / 42卷 / 01期

关键词：

trainability; aerobic exercise; exercise genetics; resistance exercise; SNPs; genetic variants; PROLIFERATOR-ACTIVATED RECEPTOR; ENZYME INSERTION/DELETION GENOTYPE; APOLIPOPROTEIN-E POLYMORPHISM; MUSCLE STRENGTH RESPONSE; GENOME-WIDE ASSOCIATION; MAXIMAL OXYGEN-UPTAKE; SKELETAL-MUSCLE; INTERINDIVIDUAL VARIABILITY; PHYSICAL PERFORMANCE; ENDURANCE CAPACITY;

D O I：

10.1055/a-1198-5496

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

This review summarised robust and consistent genetic variants associated with aerobic-related and resistance-related phenotypes. In total we highlight 12 SNPs and 7 SNPs that are robustly associated with variance in aerobic-related and resistance-related phenotypes respectively. To date, there is very little literature ascribed to understanding the interplay between genes and environmental factors and the development of physiological traits. We discuss future directions, including large-scale exercise studies to elucidate the functional relevance of the discovered genomic markers. This approach will allow more rigour and reproducible research in the field of exercise genomics.

引用

页码：3 / 18

页数：16

共 117 条

[11] Familial aggregation of VO2max response to exercise training:: results from the HERITAGE Family Study [J].

Bouchard, C ;

An, P ;

Rice, T ;

Skinner, JS ;

Wilmore, JH ;

Gagnon, J ;

Pérusse, L ;

Leon, AS ;

Rao, DC .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (03) :1003-1008

[12] Familial resemblance for VO2max in the sedentary state:: the HERITAGE Family Study [J].

Bouchard, C ;

Daw, EW ;

Rice, T ;

Pérusse, L ;

Gagnon, J ;

Province, MA ;

Leon, AS ;

Rao, DC ;

Skinner, JS ;

Wilmore, JH .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1998, 30 (02) :252-258

[13]

Bouchard C., 1983, Health Risk Estimation, P463

[14] DNA Sequence Variations Contribute to Variability in Fitness and Trainability [J].

Bouchard, Claude .

MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2019, 51 (08) :1781-1785

[15] Genomics and Genetics in the Biology of Adaptation to Exercise [J].

Bouchard, Claude ;

Rankinen, Tuomo ;

Timmons, James A. .

COMPREHENSIVE PHYSIOLOGY, 2011, 1 (03) :1603-1648

[16] Genomic predictors of the maximal O2 uptake response to standardized exercise training programs [J].

Bouchard, Claude ;

Sarzynski, Mark A. ;

Rice, Treva K. ;

Kraus, William E. ;

Church, Timothy S. ;

Sung, Yun Ju ;

Rao, D. C. ;

Rankinen, Tuomo .

JOURNAL OF APPLIED PHYSIOLOGY, 2011, 110 (05) :1160-1170

[17]

Cagnin S, 2019, SPORTS, EXERCISE, AND NUTRITIONAL GENOMICS: CURRENT STATUS AND FUTURE DIRECTIONS, P169, DOI 10.1016/B978-0-12-816193-7.00008-7

[18] Replicating genotype-phenotype associations [J].

Chanock, Stephen J. ;

Manolio, Teri ;

Boehnke, Michael ;

Boerwinkle, Eric ;

Hunter, David J. ;

Thomas, Gilles ;

Hirschhorn, Joel N. ;

Abecasis, Goncalo ;

Altshuler, David ;

Bailey-Wilson, Joan E. ;

Brooks, Lisa D. ;

Cardon, Lon R. ;

Daly, Mark ;

Donnelly, Peter ;

Fraumeni, Joseph F., Jr. ;

Freimer, Nelson B. ;

Gerhard, Daniela S. ;

Gunter, Chris ;

Guttmacher, Alan E. ;

Guyer, Mark S. ;

Harris, Emily L. ;

Hoh, Josephine ;

Hoover, Robert ;

Kong, C. Augustine ;

Merikangas, Kathleen R. ;

Morton, Cynthia C. ;

Palmer, Lyle J. ;

Phimister, Elizabeth G. ;

Rice, John P. ;

Roberts, Jerry ;

Rotimi, Charles ;

Tucker, Margaret A. ;

Vogan, Kyle J. ;

Wacholder, Sholom ;

Wijsman, Ellen M. ;

Winn, Deborah M. ;

Collins, Francis S. .

NATURE, 2007, 447 (7145) :655-660

[19] ACE genotype and the muscle hypertrophic and strength responses to strength training [J].

Charbonneau, David E. ;

Hanson, Erik D. ;

Ludlow, Andrew T. ;

Delmonico, Matthew J. ;

Hurley, Ben F. ;

Roth, Stephen M. .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (04) :677-683

[20] Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes [J].

Chen, Zhifen ;

Yu, Haojie ;

Shi, Xu ;

Warren, Curtis R. ;

Lotta, Luca A. ;

Friesen, Max ;

Meissner, Torsten B. ;

Langenberg, Claudia ;

Wabitsch, Martin ;

Wareham, Nick ;

Benson, Mark D. ;

Gerszten, Rob E. ;

Cowan, Chad A. .

CIRCULATION RESEARCH, 2020, 126 (03) :330-346

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