Mapping Robust Genetic Variants Associated with Exercise Responses

被引：15

作者：

Alvarez-Romero, Javier ^{[1
]}

Voisin, Sarah ^{[1
]}

Eynon, Nir ^{[1
,2
]}

Hiam, Danielle ^{[1
]}

机构：

[1] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia

[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia

来源：

INTERNATIONAL JOURNAL OF SPORTS MEDICINE | 2021年 / 42卷 / 01期

关键词：

trainability; aerobic exercise; exercise genetics; resistance exercise; SNPs; genetic variants; PROLIFERATOR-ACTIVATED RECEPTOR; ENZYME INSERTION/DELETION GENOTYPE; APOLIPOPROTEIN-E POLYMORPHISM; MUSCLE STRENGTH RESPONSE; GENOME-WIDE ASSOCIATION; MAXIMAL OXYGEN-UPTAKE; SKELETAL-MUSCLE; INTERINDIVIDUAL VARIABILITY; PHYSICAL PERFORMANCE; ENDURANCE CAPACITY;

D O I：

10.1055/a-1198-5496

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

This review summarised robust and consistent genetic variants associated with aerobic-related and resistance-related phenotypes. In total we highlight 12 SNPs and 7 SNPs that are robustly associated with variance in aerobic-related and resistance-related phenotypes respectively. To date, there is very little literature ascribed to understanding the interplay between genes and environmental factors and the development of physiological traits. We discuss future directions, including large-scale exercise studies to elucidate the functional relevance of the discovered genomic markers. This approach will allow more rigour and reproducible research in the field of exercise genomics.

引用

页码：3 / 18

页数：16

共 117 条

[101] Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle [J].

Taylor, D. Leland ;

Jackson, Anne U. ;

Narisu, Narisu ;

Hemani, Gibran ;

Erdos, Michael R. ;

Chines, Peter S. ;

Swift, Amy ;

Idol, Jackie ;

Didion, John P. ;

Welch, Ryan P. ;

Kinnunen, Leena ;

Saramies, Jouko ;

Lakka, Timo A. ;

Laakso, Markku ;

Tuomilehto, Jaakko ;

Parker, Stephen C. J. ;

Koistinen, Heikki A. ;

Smith, George Davey ;

Boehnke, Michael ;

Scott, Laura J. ;

Birney, Ewan ;

Collins, Francis S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (22) :10883-10888

[102] Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training [J].

Thomis, MAI ;

Huygens, W ;

Heuninckx, S ;

Chagnon, M ;

Maes, HHM ;

Claessens, AL ;

Vlietinck, R ;

Bouchard, C ;

Beunen, GP .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2004, 92 (03) :267-274

[103] Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans [J].

Timmons, James A. ;

Knudsen, Steen ;

Rankinen, Tuomo ;

Koch, Lauren G. ;

Sarzynski, Mark ;

Jensen, Thomas ;

Keller, Pernille ;

Scheele, Camilla ;

Vollaard, Niels B. J. ;

Nielsen, Soren ;

Akerstrom, Thorbjoern ;

MacDougald, Ormond A. ;

Jansson, Eva ;

Greenhaff, Paul L. ;

Tarnopolsky, Mark A. ;

van Loon, Luc J. C. ;

Pedersen, Bente K. ;

Sundberg, Carl Johan ;

Wahlestedt, Claes ;

Britton, Steven L. ;

Bouchard, Claude .

JOURNAL OF APPLIED PHYSIOLOGY, 2010, 108 (06) :1487-1496

[104] High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation [J].

Veyrieras, Jean-Baptiste ;

Kudaravalli, Sridhar ;

Kim, Su Yeon ;

Dermitzakis, Emmanouil T. ;

Gilad, Yoav ;

Stephens, Matthew ;

Pritchard, Jonathan K. .

PLOS GENETICS, 2008, 4 (10)

[105] Statistical Considerations for Exercise Protocols Aimed at Measuring Trainability [J].

Voisin, Sarah ;

Jacques, Macsue ;

Lucia, Alejandro ;

Bishop, David J. ;

Eynon, Nir .

EXERCISE AND SPORT SCIENCES REVIEWS, 2019, 47 (01) :37-45

[106] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training [J].

Walsh, S. ;

Haddad, C. J. ;

Kostek, M. A. ;

Angelopoulos, T. J. ;

Clarkson, P. M. ;

Gordon, P. M. ;

Moyna, N. M. ;

Visich, P. S. ;

Zoeller, R. F. ;

Seip, R. L. ;

Bilbie, S. ;

Thompson, P. D. ;

Devaney, J. ;

Gordish-Dressman, H. ;

Hoffman, E. P. ;

Price, Thomas B. ;

Pescatello, L. S. .

GENE, 2012, 510 (01) :66-70

[107] CNTF 1357 G → A polymorphism and the muscle strength response to resistance training [J].

Walsh, Sean ;

Kelsey, Bethany K. ;

Angelopoulos, Theodore J. ;

Clarkson, Priscilla M. ;

Gordon, Paul M. ;

Moyna, Niall M. ;

Visich, Paul S. ;

Zoeller, Robert F. ;

Seip, Richard L. ;

Bilbie, Steve ;

Thompson, Paul D. ;

Hoffman, Eric P. ;

Price, Thomas B. ;

Devaney, Joseph M. ;

Pescatello, Linda S. .

JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (04) :1235-1240

[108]

Wang G, 2016, MED SPORT SCI, V61, P55, DOI 10.1159/000445241

[109] Regulation of muscle fiber type and running endurance by PPARδ [J].

Wang, YX ;

Zhang, CL ;

Yu, RT ;

Cho, HK ;

Nelson, MC ;

Bayuga-Ocampo, CR ;

Ham, J ;

Kang, H ;

Evans, RM .

PLOS BIOLOGY, 2004, 2 (10) :1532-1539

[110] Basic science behind the cardiovascular benefits of exercise [J].

Wilson, Mathew G. ;

Ellison, Georgina M. ;

Cable, N. Tim .

BRITISH JOURNAL OF SPORTS MEDICINE, 2016, 50 (02) :93-+

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