Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions

被引：129

作者：

Bai, Tao ^{[1
]}

Liu, Sijun ^{[2
]}

Sun, Fang ^{[1
]}

Sinclair, Andrew ^{[1
]}

Zhang, Lei ^{[1
]}

Shao, Qing ^{[1
]}

Jiang, Shaoyi ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

BIOMATERIALS | 2014年 / 35卷 / 13期

基金：

美国国家科学基金会;

关键词：

Zwitterionic materials; Self-healing materials; Time-independent behavior; Zwitterionic Fusion; NANOGEL; WATER;

D O I：

10.1016/j.biomaterials.2014.01.077

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3926 / 3933

页数：8

共 34 条

[1] Construction of an ultrahigh strength hydrogel with excellent fatigue resistance based on strong dipole-dipole interaction [J].