Formation of anti- versus syn-dinuclear CuII complexes from bis-glycinamide ligands. Synergistic roles of a His/His dyad and supporting-ligand backbones in CuII binding

被引：0

作者：

Zhang, Chao ^{[1
]}

Han, Bingyang ^{[1
]}

Xu, Zichen ^{[1
]}

Yang, Chi Ming ^{[1
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Coll Chem, Biophys Organ Chem & Neurochem, Tianjin 300071, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 01期

关键词：

Backbone conformation; Decarboxylation; Dinuclear Cu-II; Bis-glycinamide; Histidine; IONIZATION MASS-SPECTROMETRY; AMYLOID-BETA PEPTIDE; ANGIOTENSIN-CONVERTING ENZYME; SUPEROXIDE-DISMUTASE; PRION PROTEIN; AMINOPOLYCARBOXYLATE COMPLEXES; CATALYTIC INACTIVATION; COPPER(II) COMPLEXES; METAL CENTERS; SITE MIMICRY;

D O I：

10.1016/j.tetlet.2015.11.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A competitive formation of 'anti' symmetric di-Cu-II and 'syn' non-symmetric decarboxylated di-Cu(II)complexes was established from a systematic study of Cu-II binding to aminocarboxylate-based bis-glycinamide ligands featuring a His/His dyad, due to the Delta-Lambda interconversion of backbone conformation which gave rise to anti versus syn binding for the 2nd Cu-II. The findings provide a facile strategy for the investigation of novel di-Cu-II mimics. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：85 / 89

页数：5