Infections and autoimmunity - friends or foes?

被引:293
作者
Kivity, Shaye [1 ,2 ]
Agmon-Levin, Nancy [1 ,3 ]
Blank, Miri [1 ]
Shoenfeld, Yehuda [1 ,3 ,4 ]
机构
[1] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52662 Tel Hashomer, Israel
[2] Chaim Sheba Med Ctr, Dept Med A&C, IL-52662 Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Dept Med B, IL-52662 Tel Hashomer, Israel
[4] Tel Aviv Univ, Sackler Fac Med, Incumbent Laura Schwarz Kip Chair Res Autoimmune, IL-39040 Tel Aviv, Israel
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATIC HEART-DISEASE; EPSTEIN-BARR-VIRUS; HELICOBACTER-PYLORI INFECTION; INFLAMMATORY-BOWEL-DISEASE; MULTIPLE-SCLEROSIS; MOLECULAR MIMICRY; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; CAMPYLOBACTER-JEJUNI;
D O I
10.1016/j.it.2009.05.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Autoimmunity can be triggered by many environmental factors, among which infectious agents are pivotal. Here, we summarize current knowledge of the relationship between infection and autoimmunity. An autoimmune disease can be induced or triggered by infectious agents, which can also determine its clinical manifestations. Most infectious agents, such as viruses, bacteria and parasites, can induce autoimmunity via different mechanisms. In many cases, it is not a single infection but rather the 'burden of infections' from childhood that is responsible for the induction of autoimmunity. The development of an autoimmune disease after infection tends to occur in genetically susceptible individuals. By contrast, some infections can protect individuals from specific autoimmune diseases (i.e. the hygiene hypothesis).
引用
收藏
页码:409 / 414
页数:6
相关论文
共 50 条
[41]   Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections [J].
Selin, Liisa K. ;
Wlodarczyk, Myriam F. ;
Kraft, Anke R. ;
Nie, Siwei ;
Kenney, Laurie L. ;
Puzone, Roberto ;
Celada, Franco .
AUTOIMMUNITY, 2011, 44 (04) :328-347
[42]   Roles of IL-1 and IL-10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes? [J].
Wu, Yi-Rou ;
Hsing, Chung-Hsi ;
Chiu, Chiao-Juno ;
Huang, Hsin-Yi ;
Hsu, Yu-Hsiang .
IUBMB LIFE, 2022, 74 (02) :143-156
[43]   HERVs, immunity, and autoimmunity: understanding the connection [J].
Greenig, Matthew .
PEERJ, 2019, 7
[44]   B lymphocytes, the gastrointestinal tract and autoimmunity [J].
Zouali, Moncef .
AUTOIMMUNITY REVIEWS, 2021, 20 (04)
[45]   The autoimmunity-oral microbiome connection [J].
Nikitakis, N. G. ;
Papaioannou, W. ;
Sakkas, L. I. ;
Kousvelari, E. .
ORAL DISEASES, 2017, 23 (07) :828-839
[46]   Infections and vaccines in the etiology of antiphospholipid syndrome [J].
Cruz-Tapias, Paola ;
Blank, Miri ;
Anaya, Juan-Manuel ;
Shoenfeld, Yehuda .
CURRENT OPINION IN RHEUMATOLOGY, 2012, 24 (04) :389-393
[47]   Herpesvirus Infections in KIR2DL2-Positive Multiple Sclerosis Patients: Mechanisms Triggering Autoimmunity [J].
Bortolotti, Daria ;
Gentili, Valentina ;
Bortoluzzi, Alessandra ;
Govoni, Marcello ;
Schiuma, Giovanna ;
Beltrami, Silvia ;
Rizzo, Sabrina ;
Baldi, Eleonora ;
Caselli, Elisabetta ;
Pugliatti, Maura ;
Castellazzi, Massimiliano ;
Fernandez, Mercedes ;
Fainardi, Enrico ;
Rizzo, Roberta .
MICROORGANISMS, 2022, 10 (03)
[48]   Targeting Toll-like Receptors in Autoimmunity [J].
Midwood, K. S. ;
Piccinini, A. M. ;
Sacre, S. .
CURRENT DRUG TARGETS, 2009, 10 (11) :1139-1155
[49]   Microbial view of central nervous system autoimmunity [J].
Berer, Kerstin ;
Krishnamoorthy, Gurumoorthy .
FEBS LETTERS, 2014, 588 (22) :4207-4213
[50]   Breastfeeding and autoimmunity: Programing health from the beginning [J].
Borba, Vania Vieira ;
Sharif, Kassem ;
Shoenfeld, Yehuda .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2018, 79 (01)