Infections and autoimmunity - friends or foes?

被引：293

作者：

Kivity, Shaye ^{[1
,2
]}

Agmon-Levin, Nancy ^{[1
,3
]}

Blank, Miri ^{[1
]}

Shoenfeld, Yehuda ^{[1
,3
,4
]}

机构：

[1] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52662 Tel Hashomer, Israel

[2] Chaim Sheba Med Ctr, Dept Med A&C, IL-52662 Tel Hashomer, Israel

[3] Chaim Sheba Med Ctr, Dept Med B, IL-52662 Tel Hashomer, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Incumbent Laura Schwarz Kip Chair Res Autoimmune, IL-39040 Tel Aviv, Israel

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 08期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATIC HEART-DISEASE; EPSTEIN-BARR-VIRUS; HELICOBACTER-PYLORI INFECTION; INFLAMMATORY-BOWEL-DISEASE; MULTIPLE-SCLEROSIS; MOLECULAR MIMICRY; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; CAMPYLOBACTER-JEJUNI;

D O I：

10.1016/j.it.2009.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmunity can be triggered by many environmental factors, among which infectious agents are pivotal. Here, we summarize current knowledge of the relationship between infection and autoimmunity. An autoimmune disease can be induced or triggered by infectious agents, which can also determine its clinical manifestations. Most infectious agents, such as viruses, bacteria and parasites, can induce autoimmunity via different mechanisms. In many cases, it is not a single infection but rather the 'burden of infections' from childhood that is responsible for the induction of autoimmunity. The development of an autoimmune disease after infection tends to occur in genetically susceptible individuals. By contrast, some infections can protect individuals from specific autoimmune diseases (i.e. the hygiene hypothesis).

引用

页码：409 / 414

页数：6

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