Concise synthesis of enantiopure α-trifluoromethyl alanines, diamines, and amino alcohols via the Strecker-type reaction

被引：78
作者：
Huguenot, Florent
Brigaud, Thierry
机构：
[1] Univ Cergy Pontoise 5, Lab SOSCO, CNRS, UMR 8123, F-95031 Cergy Pontoise, France
[2] Univ Reims, CNRS, UMR 6519, Fac Sci,Lab React Select & Applicat, F-51687 Reims 2, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 18期
关键词：
D O I：
10.1021/jo0607717
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diastereomerically pure alpha-trifluoromethyl alpha-amino nitriles obtained by Strecker-type reactions from chiral CF3 imines and iminium proved to be very attractive versatile intermediates for the synthesis of various alpha-trifluoromethyl amino compounds. From these synthons, both enantiomers of alpha-trifluoromethyl alanine, trifluoromethyl 1,2-diamines, and amino alcohols were conveniently obtained in enantiopure form in high yields in a few steps.
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页码：7075 / 7078
页数：4
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