Physicochemical Studies of Aqueous Amphiphilic Drug plus Hydrotrope Solutions

被引：1
|
作者：
Kabir-ud-Din [1 ]
Al-dahbali, Gamal A. [1 ]
Naqvi, Andleeb Z. [1 ]
Akram, Mohd. [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India
来源：
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS | 2014年 / 228卷 / 6-7期
关键词：
Amphiphilic Drugs; Hydrotropes; Surface Tension; Mixed Micelles; SODIUM-SALICYLATE SOLUTION; CHAIN-LENGTH; SURFACE; MICELLE; MICELLIZATION; SOLUBILITY; ADSORPTION; INTERFACE; BROMIDE; MODEL;
D O I：
10.1515/zpch-2013-0454
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The micellization and interfacial behaviours of two amphiphilic drugs (adephinine and clomipramine hydrochlorides) in the presence of hydrotropes (sodium salicylate and sodium benzoate) have been investigated by surface tension measurements. Micellar and interfacial compositions at different stoichiometeric mole fractions of the hydrotropes have been evaluated using Rubingh's and Rosen's models. Synergism was found in mixed micelles as well as in mixed monolayers. Thermodynamic parameters (Delta G(mic)(0), Delta G(ex), G(min), Delta G(ads)(0)) indicate that mixed systems are more stable than the individual systems with CLP-hydrotrope > ADP-hydrotrope systems.
引用
收藏
页码：731 / 745
页数：15
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