Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

被引:529
作者
Sette, A [1 ]
Sidney, J [1 ]
机构
[1] Epimmune Inc, San Diego, CA 92121 USA
关键词
vaccines; epitopes; HLA; supertypes; polymorphism; MHC;
D O I
10.1007/s002510050594
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.
引用
收藏
页码:201 / 212
页数:12
相关论文
共 121 条
[1]   Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence [J].
Ahlers, JD ;
Takeshita, T ;
Pendleton, CD ;
Berzofsky, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10856-10861
[2]  
Allen TM, 1998, J IMMUNOL, V160, P6062
[3]   A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and T-h epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen [J].
An, LL ;
Whitton, JL .
JOURNAL OF VIROLOGY, 1997, 71 (03) :2292-2302
[4]   OVERLAP IN THE REPERTOIRES OF PEPTIDES BOUND IN-VIVO BY A GROUP OF RELATED CLASS-I HLA-B ALLOTYPES [J].
BARBER, LD ;
GILLECECASTRO, B ;
PERCIVAL, L ;
LI, XB ;
CLAYBERGER, C ;
PARHAM, P .
CURRENT BIOLOGY, 1995, 5 (02) :179-190
[5]   The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C [J].
Barber, LD ;
Percival, L ;
Valiante, NM ;
Chen, L ;
Lee, C ;
Gumperz, JE ;
Phillips, JH ;
Lanier, LL ;
Bigge, JC ;
Parekh, RB ;
Parham, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :735-740
[6]  
Barber LD, 1997, J IMMUNOL, V158, P1660
[7]   Characterization of the peptide-binding specificity of HLA-B*7301 [J].
Barber, LD ;
Percival, L ;
Parham, P .
TISSUE ANTIGENS, 1996, 47 (06) :472-477
[8]   HLA-A2 SUBTYPES ARE FUNCTIONALLY DISTINCT IN PEPTIDE BINDING AND PRESENTATION [J].
BAROUCH, D ;
FRIEDE, T ;
STEVANOVIC, S ;
TUSSEY, L ;
SMITH, K ;
ROWLANDJONES, S ;
BRAUD, V ;
MCMICHAEL, A ;
RAMMENSEE, HG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1847-1856
[9]   Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor [J].
Bertoletti, A ;
Southwood, S ;
Chesnut, R ;
Sette, A ;
Falco, M ;
Ferrara, GB ;
Penna, A ;
Boni, C ;
Fiaccadori, F ;
Ferrari, C .
HEPATOLOGY, 1997, 26 (04) :1027-1034
[10]   Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis [J].
Bertoni, R ;
Sidney, J ;
Fowler, P ;
Chesnut, RW ;
Chisari, FV ;
Sette, A .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (03) :503-513