A kinetic study of the oxidation effects of amphotericin B on human low-density lipoproteins

被引：20
|
作者：
Barwicz, J [1 ]
Gruda, I [1 ]
Tancrède, P [1 ]
机构：
[1] Univ Quebec, Dept Chim Biol, Trois Rivieres, PQ G9A 5H7, Canada
来源：
FEBS LETTERS | 2000年 / 465卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
oxidation; low-density lipoprotein; amphotericin B; fungizone; AmBisome;
D O I：
10.1016/S0014-5793(99)01731-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The UV-visible results of this kinetic study show that amphothericin B as Fungizone is a much stronger oxidant than CuSO4, itself a powerful oxidant of low-density lipoprotein (LDL), Amphotericin B as AmBisome alone has no oxidizing effect on LDL while a mixture of both AmBisome and CuSO4 induces an important potentialization of the LDL oxidation. These results allow us to believe that the high toxicity of amphotericin B is related to its capacity to modify and to weaken the structure of LDL. In addition, differential scanning calorimetry experiments show that the oxidative modifications of LDL by CuSO4 or by amphotericin B proceed through different mechanisms. (C) 2000 Federation of European Biochemical Societies.
引用
收藏
页码：83 / 86
页数：4
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