Effect of salmon-calcitonin on in vitro opioid withdrawal

被引：1

作者：

Alfaro, MJ ^{[1
]}

Fernandez, B ^{[1
]}

Goicoechea, C ^{[1
]}

Martin, MI ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL,E-28040 MADRID,SPAIN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 75卷 / 01期

关键词：

morphine withdrawal; opioid abstinence; calcitonin;

D O I：

10.1254/jjp.75.101

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.

引用

页码：101 / 104

页数：4

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