The inhibition of calcium carbonate crystal growth by the cysteine-rich Mdm2 peptide

被引：17

作者：

Dalas, E. ^{[1
]}

Chalias, A. ^{[1
]}

Gatos, D. ^{[1
]}

Barlos, K. ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, GR-26504 Patras, Greece

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2006年 / 300卷 / 02期

关键词：

calcium carbonate; calcite; inhibition; Mdm2; peptide;

D O I：

10.1016/j.jcis.2006.04.003

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The crystal growth of calcite, the most stable calcium carbonate polymorph, in the presence of the cysteine-rich Mdm2 peptide (containing 48 amino acids in the ring finger configuration), has been investigated by the constant composition technique. Crystallization took place exclusively on well-characterized calcite crystals in solutions supersaturated only with respect to this calcium carbonate salt. The kinetic results indicated a surface diffusion spiral growth mechanism. The presence of the Mdm2 peptide inhibited the crystal growth of calcite by 22-58% in the concentration range tested, through adsorption onto the active growth sites of the calcite crystal surface. The kinetic results favored a Langmuir-type adsorption model, and the value of the calculated affinity constant was k(aff) = 147 x 10(4) dm(3) mol(-1), a(ads) = 0.29. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：536 / 542

页数：7

共 65 条

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