Effect of glimepiride on paraoxonase activity

被引：6
作者：
Demir, Y
Nadaroglu, H
Demir, N
机构：
[1] Ataturk Univ, Fac Educ, Dept Chem, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Oltu Tech Sch, Dept Food Technol, TR-25240 Erzurum, Turkey
[3] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey
来源：
PHARMACEUTICAL BIOLOGY | 2006年 / 44卷 / 05期
关键词：
glimepiride; heart; liver; paraoxonase; serum;
D O I：
10.1080/13880200600751717
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In this study, the effect of glimepiride on serum paraoxonase activity (EC 3.1.8.1.) has been investigated in vitro . The inhibition and activation effects of this drug on serum paraoxonase activity was measured spectrophotometrically using paraoxon as the substrate. The phenotypic distribution of paraoxonase was determined using the dual substrate paraoxon and phenyl acetate as substrates. It was observed that glimepiride inhibited serum paraoxonase activity. In addition, an in vivo study was performed for glimepiride in Sprague-Dawley rats. It was demonstrated that paraoxonase in serum, liver, and heart of Sprague-Dawley rat was significantly inhibited.
引用
收藏
页码：396 / 399
页数：4
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