Merck's Reaction Review Policy: An Exercise in Process Safety

被引：27

作者：

Bassan, Ephraim ^{[1
]}

Ruck, Rebecca T. ^{[2
]}

Dienemann, Erik ^{[1
]}

Emerson, Khateeta M. ^{[1
]}

Humphrey, Guy R. ^{[3
]}

Raheem, Izzat T. ^{[4
]}

Tschaen, David M. ^{[3
]}

Vickery, Thomas P. ^{[1
,5
]}

Wood, Harold B. ^{[5
]}

Yasuda, Nobuyoshi ^{[3
]}

机构：

[1] Merck Mfg Div, Environm & Proc Safety Engn, Rahway, NJ 07065 USA

[2] Merck Res Labs, Proc Chem, Kenilworth, NJ 07033 USA

[3] Merck Res Labs, Proc Chem, Rahway, NJ 07065 USA

[4] Merck Res Labs, Discovery Chem, West Point, PA 19486 USA

[5] Merck Res Labs, Discovery Chem, Rahway, NJ 07065 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2013年 / 17卷 / 12期

关键词：

D O I：

10.1021/op4002033

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Process safety is an important consideration not only when conducting reactions on manufacturing scale, but also on lab and kilo lab scale. This contribution presents a discussion of Merck's Reaction Review policy, originally specific to Process Chemistry and now applied broadly across the whole chemistry organization. Details of the policy and case studies are included.

引用

页码：1611 / 1616

页数：6