α-Synuclein aggregation

被引：8
|
作者：
Bodles, AM [1 ]
Irvine, GB
机构：
[1] Univ Arkansas Med Sci, Donald W Reynolds Ctr Aging, Little Rock, AR 72205 USA
[2] Queens Univ Belfast, Sch Biol & Biochem, Ctr Med Biol, Peptide & Prot Res Grp, Belfast BT9 7BL, Antrim, North Ireland
来源：
PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 03期
关键词：
alpha-synuclein; NAC; amyloid; aggregation; Parkinson's disease;
D O I：
10.2174/0929866043407084
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
alpha-Synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation..
引用
收藏
页码：271 / 279
页数：9
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