Carbohydrate-Based Polymers for Immune Modulation

被引：34
|
作者：
Lin, Kenneth [1 ]
Kasko, Andrea M. [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
来源：
ACS MACRO LETTERS | 2014年 / 3卷 / 07期
基金：
美国国家科学基金会;
关键词：
DC-SIGN; HYPERBRANCHED GLYCOPOLYMERS; RADICAL POLYMERIZATION; PROTEIN; CONJUGATE; BINDING; VACCINE; CANCER; LECTIN; INHIBITORS;
D O I：
10.1021/mz5002417
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Carbohydrates play prominent roles in immune surveillance and response to infection. Multivalency, molecular weight control, and molecular architecture control are properties that polymer science is well suited to address. Each of these properties has been demonstrated to impact the biological interaction of carbohydrate-bearing chains with their binding partners. This viewpoint highlights synthetic advances and potential applications of carbohydrate-based polymers for immune modulation. It also offers future directions in polymer science necessary for carbohydrate polymers to fulfill their potential as immune modulators.
引用
收藏
页码：652 / 657
页数：6
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