Is there a molecular connection between hypoxia and aging?

被引：29
作者：
Katschinski, DM [1 ]
机构：
[1] Univ Halle Wittenberg, D-06097 Halle, Germany
来源：
EXPERIMENTAL GERONTOLOGY | 2006年 / 41卷 / 05期
关键词：
aging; PHD; HIF-1; alpha; longevity;
D O I：
10.1016/j.exger.2005.12.003
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is associated with high incidence of ischemic diseases, which go along with a drop in tissue oxygenation. At the molecular level the hypoxia inducible factor (HIF) is the master regulator for hypoxia-induced gene expression. Recent studies demonstrated age-related changes in the HIF system, which might explain the reduced ability to cope with hypoxia in elderly. There are also some evidences that HIF is functionally connected to the aging process itself. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：482 / 484
页数：3
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