Modes of Action of Intravenous Immunoglobulin in Bullous Pemphigoid

被引：9

作者：

Li, Ning ^{[1
]}

Culton, Donna ^{[1
]}

Diaz, Luis A. ^{[1
]}

Liu, Zhi ^{[1
,2
]}

机构：

[1] Univ North Carolina Chapel Hill, Sch Med, Dept Dermatol, 2360 Genome Sci Bldg, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2018年 / 138卷 / 06期

关键词：

DISEASE; AUTOIMMUNE; MECHANISMS; THERAPY; IL-6;

D O I：

10.1016/j.jid.2018.02.020

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Bullous pemphigoid is an autoantibody-mediated skin blistering disease. Previous studies revealed that intravenous Ig is therapeutic in animal models of bullous pemphigoid by saturating the IgG-protective receptor FcRn, thereby accelerating degradation of pathogenic IgG. Sasaoka et al. demonstrate that the inhibitory effects of intravenous Ig on bullous pemphigoid are also associated with negative modulation of cytokine production by keratinocytes.

引用

页码：1249 / 1251

页数：3

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