Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases

被引：30
作者：
Kwon, Theresa [1 ]
Belot, Alexandre [2 ]
Ranchin, Bruno [2 ]
Baudouin, Veronique [1 ]
Fremeaux-Bacchi, Veronique [3 ]
Dragon-Durey, Marie-Agnes [3 ]
Cochat, Pierre [2 ]
Loirat, Chantal [1 ]
机构：
[1] Univ Paris 07, Hop Robert Debre, AP HP, Pediat Nephrol Dept, Paris, France
[2] Univ Lyon, Hosp Civils Lyon, Hop Femme Mere Enfant, Pediat Nephrol Dept, Lyon, France
[3] Univ Paris 05, AP HP, Hop Europeen Georges Pompidou, Biol Immunol Dept, Paris, France
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2009年 / 24卷 / 09期
关键词：
anti-factor H antibodies; haemolytic uraemic syndrome; MCP mutation; varicella; FACTOR-H-AUTOANTIBODIES; MEMBRANE COFACTOR PROTEIN; MUTATIONS; IMPACT; HUS;
D O I：
10.1093/ndt/gfp166
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
We report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. One of them had a membrane cofactor protein mutation, and the other had anti-factor H antibodies. These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation.
引用
收藏
页码：2752 / 2754
页数：3
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