Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished, inducible nitric oxide synthase-deficient mice with Schistosomiasis mansoni infection

被引：3

作者：

Ramos, Renata P.

Costa, Vlaudia M. A.

Melo, Camila F.

Souza, Valdenia M. O.

Malagueno, Elizabeth

Coutinho, Eridan M.

Abath, Frederico G. C.

Montenegro, Silvia M. L.

机构：

[1] Ctr Pesquisas Aggeu Magalhaes, FIOCRUZ, Dept Imunol, Lab Bioquim & Biol Mol, BR-52020020 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Lab Imunopatol Keizo Asami, Recife, PE, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2006年 / 101卷

关键词：

Schistosoma mansoni; cytokines; malnutrition; mice;

D O I：

10.1590/S0074-02762006000900053

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Schistosoma mansoni infected C57Bl/6 inducible nitric oxide synthase (iNOS)-deficient and non-deficient malnourished mice, both fed a balanced controlled diet were studied Interleukins, IL-4 and IL-10 responses to soluble egg antigens (SEA) 90 days after infection, were determined Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. We are currently investigating the biological significance of these findings.

引用

页码：331 / 332

页数：2

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