Cell Lineage Tracing and Cellular Diversity in Humans

被引：13

作者：

Abyzov, Alexej ^{[1
]}

Vaccarino, Flora M. ^{[2
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[2] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 21, 2020 | 2020年 / 21卷

关键词：

variant; genome; mitochondria; methylation; nuclear; development; MITOCHONDRIAL-DNA MUTATIONS; CAUDAL GANGLIONIC EMINENCE; STEM-CELLS; METHYLATION PATTERN; HUMAN COLON; MOUSE; FATE; FOREBRAIN; NUMBER; REVEALS;

D O I：

10.1146/annurev-genom-083118-015241

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Tracing cell lineages is fundamental for understanding the rules governing development in multicellular organisms and delineating complex biological processes involving the differentiation of multiple cell types with distinct lineage hierarchies. In humans, experimental lineage tracing is unethical, and one has to rely on natural-mutation markers that are created within cells as they proliferate and age. Recent studies have demonstrated that it is now possible to trace lineages in normal, noncancerous cells with a variety of data types using natural variations in the nuclear and mitochondrial DNA as well as variations in DNA methylation status. It is also apparent that the scientific community is on the verge of being able to make a comprehensive and detailed cell lineage map of human embryonic and fetal development. In this review, we discuss the advantages and disadvantages of different approaches and markers for lineage tracing. We also describe the general conceptual design for how to derive a lineage map for humans.

引用

页码：101 / 116

页数：16

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