Synthesis of arylacetic acid derivatives from diethyl malonate using in situ formed palladium(1,3-dialkylimidazolidin-2-ylidene) catalysts

被引：19
作者：
Özdemir, I
Yigit, M
Çetinkaya, E
Çetinkaya, B
机构：
[1] Ege Univ, Dept Chem, TR-35100 Izmir, Turkey
[2] Inonu Univ, Dept Chem, TR-44069 Malatya, Turkey
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 30期
关键词：
arylations; palladium catalysts; NHC complexes; diethyl malonate;
D O I：
10.1016/j.tetlet.2004.06.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The in situ prepared three component system Pd(OAc)(2)/1,3-bis(alkyl) imidazolinium halide LHX (1-5)/Cs2CO3 catalyses the arylation of diethyl malonate efficiently with accompanying dealkoxycarbonylation. Imidazolinium salts with bulky benzyl and alkoxyethyl groups were found to be the most efficient and afforded alpha-arylacetates in high yields when employing a wide variety of substrates. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5823 / 5825
页数：3
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