Synthesis of arylacetic acid derivatives from diethyl malonate using in situ formed palladium(1,3-dialkylimidazolidin-2-ylidene) catalysts

被引：19

作者：

Özdemir, I

Yigit, M

Çetinkaya, E

Çetinkaya, B

机构：

[1] Ege Univ, Dept Chem, TR-35100 Izmir, Turkey

[2] Inonu Univ, Dept Chem, TR-44069 Malatya, Turkey

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 30期

关键词：

arylations; palladium catalysts; NHC complexes; diethyl malonate;

D O I：

10.1016/j.tetlet.2004.06.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The in situ prepared three component system Pd(OAc)(2)/1,3-bis(alkyl) imidazolinium halide LHX (1-5)/Cs2CO3 catalyses the arylation of diethyl malonate efficiently with accompanying dealkoxycarbonylation. Imidazolinium salts with bulky benzyl and alkoxyethyl groups were found to be the most efficient and afforded alpha-arylacetates in high yields when employing a wide variety of substrates. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：5823 / 5825

页数：3

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