A Regioselective Approach to C3-Aroylcoumarins via Cobalt-Catalyzed- C(sp2)-H Activation Carbonylation of Coumarins

被引：4

作者：

Pashazadeh, Rahim ^{[1
]}

Rajai-Daryasarei, Saideh ^{[2
]}

Mirzaei, Siyavash ^{[3
]}

Soheilizad, Mehdi ^{[4
]}

Ansari, Samira ^{[4
]}

Shabanian, Meisam ^{[5
]}

机构：

[1] SOHA Pharmaceut Co, POB 31999-98461, Karaj, Iran

[2] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran

[3] ACECR, Royan Inst Reprod Biomed, Dept Genet, Tehran, Iran

[4] Alborz Univ Med Sci, CinnaGen Med Biotechnol Res Ctr, Karaj, Iran

[5] Standard Res Inst SRI Karaj, Fac Chem & Petrochem Engn, Karaj, Iran

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 15期

关键词：

cobalt-catalyzed; C-H activation; carbon monoxide; carbonylation-; 3-aroylcoumarin; H BOND FUNCTIONALIZATION; METAL-FREE ACYLATION; C-C; FACILE SYNTHESIS; ARYL METHANOLS; CARBON; ALKYLATION; ALDEHYDES; HALIDES; ARENES;

D O I：

10.1055/s-0037-1610702

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cobalt-catalyzed C-H bond activation of coumarins with aryl halides or pseudohalides and carbon monoxide insertion to give various 3-aroylcoumarin derivatives is described. It is the first time that CO as C1 feedstock is used as the coupling partners in cobalt-catalyzed regioselective coumarin C-H functionalization reactions. Upon activation with manganese powder, the Co catalyzes the C-H bond activation carbonylation reactions of aryl iodides, bromides, and even triflates under mild conditions, providing the regioselective aroylated products in moderate to good yields.

引用

页码：3014 / 3020

页数：7

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