The fatal alliance of cancer and T cells How pancreatic tumor cells gather immunosuppressive T cells

被引：7

作者：

Grage-Griebenow, Evelin ^{[1
]}

Schaefer, Heiner ^{[2
]}

Sebens, Susanne ^{[1
]}

机构：

[1] Inst Expt Med, Grp Inflammatory Carcinogenesis, Kiel, Germany

[2] Dept Internal Med, Lab Mol Gastroenterol & Hepatol, Kiel, Germany

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 06期

关键词：

immune evasion; L1CAM; pancreatic cancer; tumor microenvironment; tumor-associated inflammation; MURINE MODEL; GROWTH;

D O I：

10.4161/onci.29382

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4(+)CD25(-)CD69(+) T cells. Thus, L1CAM may serve as a target in immunomodulatory therapy for PDAC.

引用

页数：3

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