The influence of intrinsic and extrinsic factors on immune system aging

被引：9

作者：

Badowski, Michael ^{[1
]}

Shultz, Christopher L. ^{[1
]}

Eason, Yvette ^{[1
]}

Ahmad, Nafees ^{[1
]}

Harris, David T. ^{[1
]}

机构：

[1] Univ Arizona, Dept Immunobiol, Tucson, AZ 85724 USA

来源：

IMMUNOBIOLOGY | 2014年 / 219卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Aging; Immunity; OT-1; Mice; MCMV; T-CELLS; CD28; MICE; DIFFERENTIATION; SENESCENCE; EXPRESSION; PHENOTYPE;

D O I：

10.1016/j.imbio.2014.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57B1/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28(+) cells and an accumulation of KLRG1(+) T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8(+)28(-) and KLRG1(+) T cells with time. CD4(+) T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：482 / 485

页数：4

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