New strategies for the synthesis of biologically important tetrapyrroles. The "B,C+D+A" approach to linear tetrapyrroles

被引：120

作者：

Jacobi, PA ^{[1
]}

Coutts, LD

Guo, JS

Hauck, SI

Leung, SH

机构：

[1] Dartmouth Coll, Burke Chem Lab, Hanover, NH 03755 USA

[2] Wesleyan Univ, Hall Atwater Labs, Middletown, CT 06459 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 01期

关键词：

D O I：

10.1021/jo991503u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Linear tetrapyrroles related to phytochrome (1) were prepared in enantiospecific fashion by a new strategy beginning with ring-B,C synthons of type 19 (bis-iododipyrrins). Rings A and D were elaborated by Pd(0)-mediated coupling of 19a with the appropriate alkyne acid or amide derivatives 9 and 20, followed by intramolecular cyclization (method C: BC + D + A --> ABCD).

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页码：205 / 213

页数：9

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