The multiethnic cohort study: Exploring genes, lifestyle and cancer risk

被引:222
作者
Kolonel, LN
Altshuler, D
Henderson, BE [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
[2] Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA
[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA
[4] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[5] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA USA
[6] Massachusetts Gen Hosp, Diabet Unit, Boston, MA USA
关键词
D O I
10.1038/nrc1389
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The search for the causes of cancer and means of cancer prevention has entered a new era as recent developments allow correlation of environmental and behavioural exposures, genetic variation and patient outcomes. The Multiethnic Cohort Study was designed to take advantage of these advances to prospectively explore the roles of lifestyle and genetic susceptibility in the occurrence of cancer. The ethnic diversity of the cohort in this study provides a wide range of dietary exposures and genetic variation, thereby providing a unique dimension to this research.
引用
收藏
页码:519 / 527
页数:9
相关论文
共 58 条
  • [1] High-grade intra-epithelial neoplasia and prostate cancer in Dibombari, Cameroon
    Angwafo, F
    Zaher, A
    Befidi-Mengue, R
    Wonkam, A
    Takougang, I
    Powell, I
    Murphy, G
    [J]. PROSTATE CANCER AND PROSTATIC DISEASES, 2003, 6 (01) : 34 - 38
  • [2] [Anonymous], 1980, Genetic and environmental factors in experimental and human cancer
  • [3] [Anonymous], 1986, Diet, Nutrition, and Cancer
  • [4] SERUM HORMONE LEVELS IN PREMENOPAUSAL CHINESE WOMEN IN SHANGHAI AND WHITE WOMEN IN LOS-ANGELES - RESULTS FROM 2 BREAST-CANCER CASE-CONTROL STUDIES
    BERNSTEIN, L
    YUAN, JM
    ROSS, RK
    PIKE, MC
    HANISCH, R
    LOBO, R
    STANCZYK, F
    GAO, YT
    HENDERSON, BE
    [J]. CANCER CAUSES & CONTROL, 1990, 1 (01) : 51 - 58
  • [5] Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans
    Carlson, CS
    Eberle, MA
    Rieder, MJ
    Smith, JD
    Kruglyak, L
    Nickerson, DA
    [J]. NATURE GENETICS, 2003, 33 (04) : 518 - 521
  • [6] High-resolution haplotype structure in the human genome
    Daly, MJ
    Rioux, JD
    Schaffner, SE
    Hudson, TJ
    Lander, ES
    [J]. NATURE GENETICS, 2001, 29 (02) : 229 - 232
  • [7] Feigelson HS, 2001, CANCER RES, V61, P785
  • [8] Assessing the impact of population stratification on genetic association studies
    Freedman, ML
    Reich, D
    Penney, KL
    McDonald, GJ
    Mignault, AA
    Patterson, N
    Gabriel, SB
    Topol, EJ
    Smoller, JW
    Pato, CN
    Pato, MT
    Petryshen, TYL
    Kolonel, LN
    Lander, ES
    Sklar, P
    Henderson, B
    Hirschhorn, JN
    Altshuler, D
    [J]. NATURE GENETICS, 2004, 36 (04) : 388 - 393
  • [9] FRISCH RE, 1973, HUM BIOL, V45, P469
  • [10] Segregation at three loci explains familial and population risk in Hirschsprung disease
    Gabriel, SB
    Salomon, R
    Pelet, A
    Angrist, M
    Amiel, J
    Fornage, M
    Attié-Bitach, T
    Olson, JM
    Hofstra, R
    Buys, C
    Steffann, J
    Munnich, A
    Lyonnet, S
    Chakravarti, A
    [J]. NATURE GENETICS, 2002, 31 (01) : 89 - 93