OXCARBAZEPINE-INDUCED STEVENS-JOHNSON SYNDROME: A CASE REPORT

被引：35
作者：
Lin, Lung-Chang [1 ,3 ]
Lai, Ping-Chin [5 ]
Yang, Sheau-Fang [2 ]
Yang, Rei-Cheng [1 ,4 ]
机构：
[1] Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ Hosp, Dept Pathol, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Univ, Grad Inst Med, Div Physiol, Coll Med, Kaohsiung, Taiwan
[4] Kaohsiung Med Univ, Grad Inst Physiol and Mol Med, Coll Med, Kaohsiung, Taiwan
[5] Chang Gung Mem Hosp, Dept Nephrol, Taipei 10591, Taiwan
来源：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | 2009年 / 25卷 / 02期
关键词：
oxcarbazepine; Stevens-Johnson syndrome; TOXIC EPIDERMAL NECROLYSIS; CARBAMAZEPINE;
D O I：
10.1016/S1607-551X(09)70045-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B*1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied.
引用
收藏
页码：82 / 86
页数：5
相关论文
共 13 条
  • [1] Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis - Results of an international prospective study
    Auquier-Dunant, A
    Mockenhaupt, M
    Naldi, L
    Correia, O
    Schroder, W
    Roujeau, JC
    [J]. ARCHIVES OF DERMATOLOGY, 2002, 138 (08) : 1019 - 1024
  • [2] Human leukocyte antigens and drug hypersensitivity
    Chung, Wen-Hung
    Hung, Shuen-Lu
    Chen, Yuan-Tsong
    [J]. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 7 (04) : 317 - 323
  • [3] A marker for Stevens-Johnson syndrome
    Chung, WH
    Hung, SI
    Hong, HS
    Hsih, MS
    Yang, LC
    Ho, HC
    Wu, JY
    Chen, YT
    [J]. NATURE, 2004, 428 (6982) : 486 - 486
  • [4] Devi K, 2005, Indian J Dermatol Venereol Leprol, V71, P325
  • [5] Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: A prospective study in adult and elderly patients with newly diagnosed partial epilepsy
    Dogan, Ebru Apaydin
    Usta, Burcu Ekmekci
    Bilgen, Rengin
    Senol, Yesim
    Aktekin, Berrin
    [J]. EPILEPSY & BEHAVIOR, 2008, 13 (01) : 156 - 161
  • [6] Frisch P O, 2003, FITZPATRICKS DERMATO, P543
  • [7] Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel
    Halevy, Sitna
    Ghislain, Pierre-Dominique
    Mockenhaupt, Maja
    Fagot, Jean-Paul E.
    Bavinck, Jan Nico Bouwes
    Sidoroff, Alexis
    Naldi, Luigi
    Dunant, Ariane
    Viboud, Cecile
    Roujeau, Jean-Claude
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (01) : 25 - 32
  • [8] Lam Nga-Shuen, 2004, Journal of Microbiology Immunology and Infection, V37, P366
  • [9] Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics
    Mockenhaupt, M
    Messenheimer, J
    Tennis, P
    Schlingmann, J
    [J]. NEUROLOGY, 2005, 64 (07) : 1134 - 1138
  • [10] TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients
    Pirmohamed, M
    Lin, K
    Chadwick, D
    Park, BK
    [J]. NEUROLOGY, 2001, 56 (07) : 890 - 896
12