Are there meaningful biomarkers of treatment response for depression?

被引：49

作者：

Breitenstein, Barbara ^{[1
,2
]}

Scheuer, Sandra ^{[2
]}

Holsboer, Florian ^{[1
,2
]}

机构：

[1] HolsboerMaschmeyerNeuroChemie, Munich, Germany

[2] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 05期

关键词：

CATECHOL-O-METHYLTRANSFERASE; SEROTONIN TRANSPORTER GENE; NEUROTROPHIC FACTOR GENE; ANTIDEPRESSANT TREATMENT RESPONSE; CORTICOTROPIN-RELEASING-FACTOR; TERM TREATMENT RESPONSE; COMBINED DEXAMETHASONE/CRH TEST; LINKED POLYMORPHIC REGION; PREDICTS TREATMENT RESPONSE; ANTERIOR CINGULATE ACTIVITY;

D O I：

10.1016/j.drudis.2014.02.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During the past decades, the prevalence of affective disorders has been on the rise globally, with only one out of three patients achieving remission in acute treatment with antidepressants. The identification of physiological markers that predict treatment course proves useful in increasing therapeutic success. On the basis of well-documented, recent findings in depression research, we highlight and discuss the most promising biomarkers for antidepressant therapy response. These include genetic variants and gene expression profiles, proteomic and metabolomic markers, neuroendocrine function tests, electrophysiology and imaging techniques. Ultimately, this review proposes an integrative use of biomarkers for antidepressant treatment outcome.

引用

页码：539 / 561

页数：23

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