Carotid Stiffness Is Associated With Incident Stroke A Systematic Review and Individual Participant Data Meta-Analysis

被引:171
作者
van Sloten, Thomas T. [1 ,2 ,3 ]
Sedaghat, Sanaz [4 ]
Laurent, Stephane [5 ,6 ]
London, Gerard M. [7 ]
Pannier, Bruno [8 ]
Ikram, M. Arfan [4 ,9 ,10 ]
Kavousi, Maryam [4 ]
Mattace-Raso, Francesco [11 ]
Franco, Oscar H. [4 ]
Boutouyrie, Pierre [5 ,6 ]
Stehouwer, Coen D. A. [1 ,2 ]
机构
[1] Maastricht Univ, Med Ctr, Dept Internal Med, NL-6229 HX Maastricht, Netherlands
[2] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, NL-6229 HX Maastricht, Netherlands
[3] Maastricht Univ, Med Ctr, Sch Nutr Toxicol & Metab, NL-6229 HX Maastricht, Netherlands
[4] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
[5] Univ Paris 05, HEGP, AP HP, Inserm U970, Paris, France
[6] Georges Pompidou European Hosp, Dept Pharmacol, Paris, France
[7] Hop Manhes, Paris, France
[8] Ctr Invest Prevent & Clin IPC Ctr, Paris, France
[9] Erasmus MC, Dept Radiol, Rotterdam, Netherlands
[10] Erasmus MC, Dept Neurol, Rotterdam, Netherlands
[11] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
关键词
arterial stiffness; cardiovascular disease; risk classification; ALL-CAUSE MORTALITY; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; ARTERIAL STIFFNESS; CARDIOVASCULAR EVENTS; VASCULAR EVENTS; RISK PROFILE; PREDICTION; DIAMETER; DISTENSIBILITY;
D O I
10.1016/j.jacc.2015.08.888
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND Carotid stiffening is considered a key element in the pathogenesis of stroke. However, results of studies evaluating the association between carotid stiffness and incident stroke have been inconsistent. OBJECTIVES This study investigated whether carotid stiffness (as determined by ultrasonography) is associated with incident stroke and whether this association is independent of aortic stiffness as estimated by carotid-femoral pulse wave velocity (cfPWV). Additionally, we evaluated the incremental value of carotid stiffness for stroke risk prediction beyond Framingham risk factors and cfPWV. METHODS This study included a systematic review and meta-analyses of aggregate and individual participant data (IPD), the latter of which was obtained by requesting individual-level data of all cohort studies with available data on carotid stiffness and cfPWV. RESULTS Ten studies (n = 22,472) were included in the aggregate data meta-analysis and 4 (n = 4,540) in the IPD meta-analysis. After adjusting for cardiovascular (CV) factors, the aggregate data meta-analysis showed that greater carotid stiffness (per SD) was associated with stroke (hazard ratio: 1.18; 95% confidence interval: 1.05 to 1.33). In addition, carotid stiffness was associated with total CV events and CV and all-cause mortality, but not with coronary heart disease events. In the IPD meta-analysis, additional adjustment for cfPWV did not materially change these associations. Carotid stiffness did improve stroke risk prediction beyond Framingham and cfPWV (integrative discrimination improvement: 0.4 percentage point [95% confidence interval: 0.1 to 0.6 percentage point] and continuous net reclassification improvement: 18.6% [95% confidence interval: 5.8% to 31.3%]). CONCLUSIONS Carotid stiffness is associated with incident stroke independently of CV factors and aortic stiffness. In addition, carotid stiffness improves stroke risk prediction beyond Framingham and aortic stiffness. (C) 2015 by the American College of Cardiology Foundation.
引用
收藏
页码:2116 / 2125
页数:10
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