Predictive value of vitamin D plasma levels on pregnancy rates in a cohort of IVF patients

Objective. - To determine a possible correlation between plasma levels of vitamin D and pregnancy rates obtained by in vitro fertilization (IVF). Patients and methods. - One hundred and ninety-eight womens participated in an IVF cycle from January to May 2012 in a prospective study. During the follicular phase locking, serum fluid was collected for vitamin D, calcium, FSH and estradiol analysis. The serum beta hCG was checked 16 days after oocyte collect. Clinical pregnancy was confirmed by transvaginal sonography with at least one gestational sac in the uterine cavity. Results. - The mean levels of vitamin D was 31.7 nmol/L A total of 169 patients (85.3%) had a vitamin D insufficiency ( < 50 nmol/L). Only 29 patients (14.7%) had a sufficient vitamin D status (vitamin D >= 50 nmol/L). Pregnancy rate was 29.8% (59/198). There was no significant correlation between the levels of vitamin D and mean age (P = 0.92), BMI (P = 0.16) and etiology of infertility (P = 0.78). In contrast, the levels of vitamin D mean were significantly lower in patients from North Africa (P < 0.0001) and Black African (P = 0.0003) compared to Caucasian patients. Discussion and conclusion. - No correlation was found between serum vitamin D level and the pregnancy rate in IVF cycle. (C) 2015 Elsevier Masson SAS. All rights reserved.