Immune effects of 5-fluorouracil Ambivalence matters

被引：35

作者：

Ghiringhelli, Francois ^{[1
,2
,3
]}

Bruchard, Melanie ^{[1
,3
]}

Apetoh, Lionel ^{[1
,2
,3
]}

机构：

[1] INSERM, U866, Dijon, France

[2] Ctr Georges Francois Leclerc, Dijon, France

[3] Univ Bourgogne, Dijon, France

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

IL1; NLRP3; fluorouracil; inflammasome; myeloid derived suppressor cells; CELLS;

D O I：

10.4161/onci.23139

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting T(H)17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.

引用

页数：2

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