Immediate and Delayed Reactions to Radiocontrast Media: Is There an Allergic Mechanism?

被引：59

作者：

Brockow, Knut ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, D-80802 Munich, Germany

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2009年 / 29卷 / 03期

关键词：

Radiocontrast media; Hypersensitivity; Skin test; Diagnosis; Immediate; Non-immediate; Mechanism; RADIOGRAPHIC CONTRAST-MEDIA; TOXIC EPIDERMAL NECROLYSIS; ADVERSE-REACTIONS; HYPERSENSITIVITY REACTIONS; HISTAMINE-RELEASE; ANAPHYLACTOID REACTIONS; GENERALIZED REACTIONS; INVITRO HISTAMINE; T-CELLS; SKIN;

D O I：

10.1016/j.iac.2009.04.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Radiocontrast media can cause immediate (1 hour) and nonimmediate (>1 hour) hypersensitivity reactions that remain unpredictable and a cause of concern for radiologists and cardiologists. Immediate hypersensitivity reactions resemble anaphylaxis, whereas nonimmediate ones clinically are predominated by exanthemas. Increasing evidence indicates that immediate reactions and nonimmediate skin exanthemas may be allergic reactions involving either contrast media-reactive IgE or T cells, respectively. Skin testing is a useful tool for the diagnosis of contrast media allergy. It may have an important role in the selection of a safe product in previous reactors, although validation data are still lacking. In vitro tests to search for contrast media-specific cell activation are currently under investigation.

引用

页码：453 / +

页数：17

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