Application of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation

被引：9

作者：

Duc Ba Nguyen ^{[1
,2
]}

Mok, Young Sun ^{[1
]}

Do Luoung Huynh ^{[3
]}

Jeong, Dong Kee ^{[3
]}

Lee, Wong Gyu ^{[4
]}

机构：

[1] Jeju Natl Univ, Dept Chem & Biol Engn, Jeju 63243, South Korea

[2] Duy Tan Univ, Ctr Adv Chem, Inst Res & Dev, Da Nang, Vietnam

[3] Jeju Natl Univ, Dept Adv Convergence Technol & Sci, Jeju, South Korea

[4] Kangwon Natl Univ, Div Chem Engn & Bioengn, Chunchon, Kangwon, South Korea

来源：

PLASMA PROCESSES AND POLYMERS | 2019年 / 16卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

cold plasma; dielectric barrier discharges (DBD); He plasma jet; plasma jet; plasma-activated medium;

D O I：

10.1002/ppap.201800173

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In vitro treatment of hepatic malignant cells with plasma-activated medium conjugated with gemcitabine was investigated with a He plasma jet generated by a two-ring dielectric barrier discharge (DBD) reactor. The DBD reactor was operated by high-voltage pulses of alternating polarity (frequency: 20 kHz; pulse width: 4 mu s). The electron density of plasma plume was estimated to be 9x10(12) to 10x10(12) cm(-3), and the jet temperature was around 36celcius. The plasma jet exhibited the inhibitory effects on the growth of hepatic malignant cells via the generation of reactive oxygen species, which could be potentially applicative in anticancer therapies. The optimization of the operating parameters and configuration of the plasma jet would help increase the possibility in practical cancer treatments.

引用

页数：8

共 44 条

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