Primary cutaneous diffuse large B cell lymphomaother successfully treated by the combination of R-CHOP chemotherapy and surgery A case report and review of literature

Rationale: The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP ( A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed. Patient concerns: The patient was a 56-year-old female, presenting with red plaques and nodules in her left breast for 6 months. Diagnoses: Based on the clinical manifestation, histopathological and immunohistochemical results, the patient was diagnosed with PCDLBCL-O. Interventions: She was treated with 6 courses of R-CHOP chemotherapy combined with surgical resection. Outcomes: In the present case, fairly good curative effect was appeared with no recurrence within the 3 years' follow-up. Lessons: Primary cutaneous diffuse large B cell lymphoma commonly occurs on the legs ( leg type), rarely on other sites of the body. The clinical manefestations are so variant that its diagnosis depends on histopathological and immunohistochemical examinations. Like systemic diffuse large B cell lymphoma, patients should be treated with systemic chemotherapy. Abbreviations: CR = complete remission, DLBCL = diffuse large B cell lymphoma, PCBCL = primary cutaneous B cell lymphoma, PCDLBCL = primary cutaneous diffuse large B cell lymphoma, PCFCL = primary cutaneous follicle-center lymphoma, PCMZL = primary cutaneous marginal zone B cell lymphoma.