Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat

被引：30
|
作者：
Kasa, P
Papp, H
Kovacs, I
Forgon, M
Penke, B
Yamaguchi, H
机构：
[1] Albert Szent Gyorgyi Med Univ, Alzheimers Dis Res Ctr, H-6720 Szeged, Hungary
[2] Albert Szent Gyorgyi Med Univ, Dept Med Chem, H-6720 Szeged, Hungary
[3] Gunma Univ, Coll Med Care & Technol, Maebashi, Gumma 371, Japan
来源：
NEUROSCIENCE LETTERS | 2000年 / 278卷 / 1-2期
基金：
匈牙利科学研究基金会;
关键词：
Alzheimer's disease; amyloid; axonal transport; immunohistochemistry; neurotoxicity; sciatic nerve;
D O I：
10.1016/S0304-3940(99)00863-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Human amyloid-beta 1-42 has been suggested to be a pathogenetic factor in Alzheimer's disease. The precise mechanism by which this peptide causes the degeneration of neurons in the affected brain is not yet fully understood. By using immunohistochemistry we explored the inhibitory effects of human amyloid-beta 1-42 applied in vivo on the fast axonal transport of acetylcholinesterase, the amyloid precursor protein, the vesicular acetylcholine transporter and synaptophysin in the sciatic nerve of rat. Our findings provide evidence for the in vivo neurotoxic effect of human amyloid-beta peptide. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：117 / 119
页数：3
相关论文
共 50 条
  • [31] Amyloid-β1-42 Treatment Does Not Have a Specific Effect on Cholinergic Neurons in in vitro Basal Forebrain Neuronal Cultures of Rat
    Henrietta Papp
    P. Kása
    Magdolna Pákáski
    L. Baláspiri
    P. Kása
    Acta Biologica Hungarica, 2002, 53 : 257 - 265
  • [32] Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1-42 Aggregation
    Li, Ke Sherry
    Rempel, Don L.
    Gross, Michael L.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (37) : 12090 - 12098
  • [33] Protective effects of idebenone and α-tocopherol on β-amyloid-(1-42)-induced learning and memory deficits in rats:: implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
    Yamada, K
    Tanaka, T
    Han, D
    Senzaki, K
    Kameyama, T
    Nabeshima, T
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (01) : 83 - 90
  • [34] Amyloid-β25-35, an Amyloid-β1-42 Surrogate, and Proinflammatory Cytokines Stimulate VEGF-A Secretion by Cultured, Early Passage, Normoxic Adult Human Cerebral Astrocytes
    Chiarini, Anna
    Whitfield, James
    Bonafini, Clara
    Chakravarthy, Balu
    Armato, Ubaldo
    Dal Pra, Ilaria
    JOURNAL OF ALZHEIMERS DISEASE, 2010, 21 (03) : 915 - 926
  • [35] Neuroprotective effects of a Rhodiola crenulata extract on amyloid-β peptides (Aβ1-42) -induced cognitive deficits in rat models of Alzheimer's disease
    Zhang Xiaoxue
    Wang Xue
    Hu Xinhua
    Chu Xiaowen
    Li Xintong
    Han Fei
    PHYTOMEDICINE, 2019, 57 : 331 - 338
  • [36] Difference in ability for extracellular Zn2+ influx between human and rat amyloid β1-42 and its significance
    Tamano, Haruna
    Suzuki, Hiroki
    Kobuchi, Shuhei
    Adlard, Paul A.
    Bush, Ashley I.
    Takeda, Atsushi
    NEUROTOXICOLOGY, 2019, 72 : 1 - 5
  • [37] Amyloid-β(1-42) Fibrillar Precursors Are Optimal for Inducing Tumor Necrosis Factor-α Production in the THP-1 Human Monocytic Cell Line
    Ajit, Deepa
    Udan, Maria L. D.
    Paranjape, Geeta
    Nichols, Michael R.
    BIOCHEMISTRY, 2009, 48 (38) : 9011 - 9021
  • [38] Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells
    Meng, Pengfei
    Yoshida, Hidemi
    Tanji, Kunikazu
    Matsumiya, Tomoh
    Xing, Fei
    Hayakari, Ryo
    Wang, Liang
    Tsuruga, Kazushi
    Tanaka, Hiroshi
    Mimura, Junsei
    Kosaka, Kunio
    Itoh, Ken
    Takahashi, Ippei
    Kawaguchi, Shogo
    Imaizumi, Tadaatsu
    NEUROSCIENCE RESEARCH, 2015, 94 : 1 - 9
  • [39] Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-β1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model
    Brouillette, Jonathan
    Caillierez, Raphaelle
    Zommer, Nadege
    Alves-Pires, Claire
    Benilova, Iryna
    Blum, David
    De Strooper, Bart
    Buee, Luc
    JOURNAL OF NEUROSCIENCE, 2012, 32 (23) : 7852 - 7861
  • [40] The nicotinic α7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-β1-42
    Soderman, Andreas
    Thomsen, Morten S.
    Hansen, Henrik H.
    Nielsen, Elsebet O.
    Jensen, Morten S.
    West, Mark J.
    Mikkelsen, Jens D.
    BRAIN RESEARCH, 2008, 1227 : 240 - 247
12345