Objective: To explore the role of high-quality nursing (HQN) on the skin pruritus and nursing satisfaction of patients with cholestatic liver disease (CLD)-induced skin pruritus. Methods: Patients with CLD were recruited for this study at our hospital from May 2018 to December 2019 and placed into a research group (RG) (38 cases) and a control group (CG) (35 cases) according to the nursing method each received. The RG underwent HQN intervention. The CG underwent routine nursing intervention. The nursing effect, QOL, sleep quality, and the satisfaction with the nursing of the pruritus symptoms in the two groups were compared. Results: The total effective rates of the pruritus nursing and the degree of satisfaction with the nursing in the RG were significantly higher than they were in the CG (P < 0.05), and the onset time and skin improvement time were significantly lower than they were in the CG (P < 0.05). There was no apparent difference in the DLQI, AIS, SAS, or SDS scores between the RG and the CG before the nursing (P > 0.05). After 3 months of treatment, the DLQI, AIS, SAS, and SDS scores in the RG and the CG were lower than they were before the treatment (P < 0.05), and the DLQI, AIS, SAS, and SDS scores in the RG after the nursing were lower than they were in the CG (P < 0.05). Conclusion: HQN for patients with CLD is effective and can effectively relieve the skin pruritus symptoms and improve the patients' satisfaction with the nursing and their quality of life.