The growth of biomedical terahertz research

被引:142
作者
Fan, Shuting [1 ]
He, Yuezhi [2 ]
Ung, Benjamin S. [2 ]
Pickwell-MacPherson, Emma [2 ]
机构
[1] Univ Sci & Technol, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Shatin, Hong Kong, Peoples R China
关键词
terahertz imaging; terahertz spectroscopy; biomedical; BASAL-CELL CARCINOMA; HUMAN BREAST-CANCER; PULSED SPECTROSCOPY; EX-VIVO; IN-VIVO; VIBRATIONAL DYNAMICS; LIQUID WATER; THZ; RADIATION; CRYSTALLINITY;
D O I
10.1088/0022-3727/47/37/374009
中图分类号
O59 [应用物理学];
学科分类号
摘要
Interest in biomedical terahertz research is growing rapidly and there are now several terahertz groups in Asia, Europe and the US investigating potential applications such as pharmaceutical quality control, protein characterization and cancer detection. This review article outlines the technological bottlenecks that have been overcome which have made biomedical terahertz research possible. Key research findings will be presented, and the limitations that remain and the research initiatives that strive to address them will also be discussed.
引用
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页数:11
相关论文
共 73 条
[1]   The solid-state terahertz spectrum of MDMA (Ecstasy) - A unique test for molecular modeling assignments [J].
Allis, Damian G. ;
Hakey, Patrick M. ;
Korter, Timothy M. .
CHEMICAL PHYSICS LETTERS, 2008, 463 (4-6) :353-356
[2]   Terahertz pulsed spectroscopy of freshly excised human breast cancer [J].
Ashworth, Philip C. ;
Pickwell-MacPherson, Emma ;
Provenzano, Elena ;
Pinder, Sarah E. ;
Purushotham, Anand D. ;
Pepper, Michael ;
Wallace, Vincent P. .
OPTICS EXPRESS, 2009, 17 (15) :12444-12454
[3]  
Auston D, 2008, APPL PHYS LETT, V26, P101
[4]  
Awad M, 2007, 15 INT C TER EL IRMM, P190
[5]   The terahertz dance of water with the proteins: the effect of protein flexibility on the dynamical hydration shell of ubiquitin [J].
Born, Benjamin ;
Kim, Seung Joong ;
Ebbinghaus, Sinion ;
Gruebele, Martin ;
Havenith, Martina .
FARADAY DISCUSSIONS, 2009, 141 :161-173
[6]   Solvation Dynamics of Model Peptides Probed by Terahertz Spectroscopy. Observation of the Onset of Collective Network Motions [J].
Born, Benjamin ;
Weingaertner, Hermann ;
Bruendermann, Erik ;
Havenith, Martina .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (10) :3752-3755
[7]   Terahertz imaging with compressed sensing and phase retrieval [J].
Chan, Wai Lam ;
Moravec, Matthew L. ;
Baraniuk, Richard G. ;
Mittleman, Daniel M. .
OPTICS LETTERS, 2008, 33 (09) :974-976
[8]   A single-pixel terahertz imaging system based on compressed sensing [J].
Chan, Wai Lam ;
Charan, Kriti ;
Takhar, Dharmpal ;
Kelly, Kevin F. ;
Baraniuk, Richard G. ;
Mittleman, Daniel M. .
APPLIED PHYSICS LETTERS, 2008, 93 (12)
[9]   High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model [J].
Chen, Hua ;
Chen, Te-Hsuen ;
Tseng, Tzu-Fang ;
Lu, Jen-Tang ;
Kuo, Chung-Chiu ;
Fu, Shih-Chen ;
Lee, Wen-Jeng ;
Tsai, Yuan-Fu ;
Huang, Yi-You ;
Chuang, Eric Y. ;
Hwang, Yuh-Jing ;
Sun, Chi-Kuang .
OPTICS EXPRESS, 2011, 19 (22) :21552-21562
[10]   Terahertz dielectric assay of solution phase protein binding [J].
Chen, Jing-Yin ;
Knab, J. R. ;
Ye, Shuji ;
He, Yunfen ;
Markelz, A. G. .
APPLIED PHYSICS LETTERS, 2007, 90 (24)