Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101

被引：75
作者：
Waites, Ken B. [1 ]
Crabb, D. M. [1 ]
Duffy, Lynn B. [1 ]
机构：
[1] Univ Alabama, Dept Pathol, Birmingham, AL 35249 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期
关键词：
MACROLIDE RESISTANCE; PNEUMONIAE; ANTIMICROBIALS; GENE;
D O I：
10.1128/AAC.00090-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
MICs were determined for an investigational ketolide, CEM-101, and azithromycin, telithromycin, doxycycline, levofloxacin, clindamycin, and linezolid against 36 Mycoplasma pneumoniae, 5 Mycoplasma genitalium, 13 Mycoplasma hominis, 15 Mycoplasma fermentans, and 20 Ureaplasma isolates. All isolates, including two macrolide-resistant M. pneumoniae isolates, were inhibited by CEM-101 at <= 0.5 mu g/ml, making CEM-101 the most potent compound tested.
引用
收藏
页码：2139 / 2141
页数：3
相关论文
共 21 条
[11]   Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia [J].
Morozumi, Miyuki ;
Iwata, Satoshi ;
Hasegawa, Keiko ;
Chiba, Naoko ;
Takayanagi, Reiko ;
Matsubara, Keita ;
Nakayama, Eiichi ;
Sunakawa, Keisuke ;
Ubukata, Kimiko .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (01) :348-350
[12]   First report of macrolide-resistant strains and description of a novel nucleotide sequence variation in the P1 adhesin gene in Mycoplasma pneumoniae clinical strains isolated in France over 12 years [J].
Pereyre, S. ;
Charron, A. ;
Renaudin, H. ;
Bebear, C. ;
Bebear, C. M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (11) :3534-3539
[13]  
ROBLIN PM, 2008, 48 INT C ANT AG CHEM
[14]   Clinical evaluation of macrolide-resistant Mycoplasma pneumoniae [J].
Suzuki, S ;
Yamazaki, T ;
Narita, M ;
Okazaki, N ;
Suzuki, I ;
Andoh, T ;
Matsuoka, M ;
Kenri, T ;
Arakawa, Y ;
Sasaki, T .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :709-712
[15]   Mycoplasma pneumoniae and its role as a human pathogen [J].
Waites, KB ;
Talkington, DF .
CLINICAL MICROBIOLOGY REVIEWS, 2004, 17 (04) :697-+
[16]   Mycoplasmas and ureaplasmas as neonatal pathogens [J].
Waites, KB ;
Katz, B ;
Schelonka, RL .
CLINICAL MICROBIOLOGY REVIEWS, 2005, 18 (04) :757-+
[17]   In vitro activities of ABT-773 and other antimicrobials against human mycoplasmas [J].
Waites, KB ;
Crabb, DA ;
Duffy, LB .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :39-42
[18]  
WAITES KB, 2007, MANUAL CLIN MICROBIO, V1, P1004
[19]  
WAITES KB, 2004, CLIN MICROBIOLOGY PR, V1
[20]   Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis [J].
Wolff, Bernard J. ;
Thacker, W. Lanier ;
Schwartz, Stephanie B. ;
Winchell, Jonas M. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) :3542-3549
123