Structural changes in patients with primary generalized tonic and clonic seizures

被引：92

作者：

Ciumas, Carolina ^{[1
]}

Savic, Ivanka ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Univ Hosp, MR Ctr, Dept Neurol,Dept Clin Neurosci, S-17176 Stockholm, Sweden

来源：

NEUROLOGY | 2006年 / 67卷 / 04期

关键词：

DISCHARGES; ACTIVATION;

D O I：

10.1212/01.wnl.0000230171.23913.cf

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted MR volumetry and voxel-based morphometry in 19 patients who had idiopathic generalized epilepsy (IGE) with tonic clonic seizures as the only seizure type and 52 control subjects. Patients exhibited elevated frontal lobe fraction of CSF and reduced fraction of gray matter in the frontal, parietal, temporal cortex, thalamus, and cerebellum. The thalamus and cerebellum also showed reduced volumes, as did the caudate and putamen. Contrary to current diagnostic criteria, regional tissue abnormalities may be present in IGE.

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页码：683 / 686

页数：4

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