Simple and efficient synthesis of tetrahydro-β-carbolines via the Pictet-Spengler reaction in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)

被引：37

作者：

Wang, Li-Na ^{[1
]}

Shen, Su-Li ^{[1
]}

Qu, Jin ^{[1
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 58期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSPECIFIC TOTAL-SYNTHESIS; MONOTERPENOID INDOLE ALKALOIDS; SURFACTANT-COMBINED CATALYST; FLUORINATED ALCOHOLS; MULTIDRUG-RESISTANCE; FUMITREMORGIN C; AROMATIC-AMINES; ACID CATALYST; AQUEOUS-MEDIA; TETRAHYDROISOQUINOLINES;

D O I：

10.1039/c4ra03628j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) can act as both the solvent and the catalyst to promote the Pictet-Spengler reactions between tryptamine derivatives and aldehydes or activated ketones. For most substrates, removing the low boiling point HFIP by distillation directly afforded tetrahydro-beta-carbolines in high yields.

引用

页码：30733 / 30741

页数：9

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