Treatment of Primary Biliary Cirrhosis: Therapy with Choleretic and Immunosuppressive Agents

被引：22

作者：

Silveira, Marina G. ^{[1
]}

Lindor, Keith D. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Miles & Shirley Fiterman Ctr Digest Dis, Rochester, MN 55905 USA

来源：

CLINICS IN LIVER DISEASE | 2008年 / 12卷 / 02期

关键词：

D O I：

10.1016/j.cld.2008.02.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology affecting predominantly middle-aged women; it is a slowly progressive disease causing loss of intrahepatic bile ducts, resulting hi advanced fibrosis, cirrhosis, and liver failure. Many drugs have been studied for treatment, including agents with choleretic and immunosuppressive properties. Ursodeoxycholic acid (UDCA) has been evaluated most widely. After fiver failure, the only effective treatment is liver transplantation. Effective therapy reduces the need for transplantation and improves life expectancy. For advanced liver disease or incomplete response to UDCA, new therapies to cure or retard the progression of disease in PBC are needed.

引用

页码：425 / +

页数：21

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