Severe exacerbation of hepatitis C-associated vasculitic neuropathy following treatment with interferon alpha: A case report and literature review

被引：66

作者：

Boonyapisit, K ^{[1
]}

Katirji, B ^{[1
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Cleveland, Dept Neurol, Cleveland, OH 44106 USA

来源：

MUSCLE & NERVE | 2002年 / 25卷 / 06期

关键词：

hepatitis C neuropathy; hepatitis C virus; interferon alpha; vasculitic neuropathy;

D O I：

10.1002/mus.10118

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vasculitic neuropathy may occur in association with chronic hepatitis C infection. Interferon alpha (IFNalpha), an effective treatment for chronic hepatitis C, can precipitate or worsen autoimmune diseases. We report a patient with chronic hepatitis C and mild indolent vasculitic sensorimotor peripheral polyneuropathy, who developed severe mononeuropathy multiplex soon after IFNalpha was initiated, and review the literature on worsening vasculitic neuropathy after IFNalpha treatment for chronic hepatitis C. Care should be taken after starting patient with chronic hepatitis C-associated vasculitic neuropathy on IFNalpha, as there is evidence that IFNalpha may exacerbate the neuropathy. (C) 2002 Wiley Periodicals, Inc.

引用

页码：909 / 913

页数：5

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