Rapid chloride analysis using miniaturised isotachophoresis

被引：9
作者：
Prest, JE [1 ]
Baldock, SJ [1 ]
Fielden, PR [1 ]
Goddard, NJ [1 ]
Mohr, S [1 ]
Brown, BJT [1 ]
机构：
[1] Univ Manchester, Sch Chem Engn & Analyt Sci, Manchester M60 1QD, Lancs, England
来源：
JOURNAL OF CHROMATOGRAPHY A | 2006年 / 1119卷 / 1-2期
基金：
英国工程与自然科学研究理事会;
关键词：
isotachophoresis; miniaturisation; microdevice; chip; chloride analysis; conductivity detection;
D O I：
10.1016/j.chroma.2005.11.030
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 nM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l(-1). (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：183 / 187
页数：5
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