H9N2 influenza virus isolated from minks has enhanced virulence in mice

被引：19

作者：

Xue, R. ^{[1
]}

Tian, Y. ^{[1
,2
,3
]}

Hou, T. ^{[2
]}

Bao, D. ^{[2
]}

Chen, H. ^{[2
]}

Teng, Q. ^{[2
]}

Yang, J. ^{[2
]}

Li, X. ^{[2
]}

Wang, G. ^{[4
]}

Li, Z. ^{[2
]}

Liu, Q. ^{[2
]}

机构：

[1] Shandong Agr Univ, Coll Anim Sci & Technol, Tai An, Shandong, Peoples R China

[2] CAAS, Shanghai Vet Res Inst, Shanghai, Peoples R China

[3] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol & Zoonoses, Minist Agr, Beijing, Peoples R China

[4] Shandong Prov Ctr Anim Dis Control & Prevent, Jinan, Shandong, Peoples R China

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2018年 / 65卷 / 03期

基金：

中国国家自然科学基金;

关键词：

701N; H9N2; influenza A virus; mink; pathogenicity; phylogenetic analysis; AVIAN INFLUENZA; A-VIRUS; POULTRY WORKERS; INFECTION; CHINA; EVOLUTION;

D O I：

10.1111/tbed.12805

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

H9N2 is one of the major subtypes of influenza virus circulating in poultry in China, which has a wide host range from bird to mammals. Two H9N2 viruses were isolated from one mink farm in 2014. Phylogenetic analysis showed that internal genes of the H9N2 viruses have close relationship with those of H7N9 viruses. Interestingly, two H9N2 were separated in phylogenetic trees, indicating that they are introduced to this mink farm in two independent events. And further mice studies showed that one H9N2 caused obvious weight loss and 20% mortality in infected mice, while another virus did not cause any clinical sign in mice infected at the same dose. Genetic analysis indicated that the virulent H9N2 contain a natural mutation at 701N in PB2 protein, which was reported to contribute to mammalian adaptation. However, such substitution is absent in the H9N2 avirulent to mice. Circulation of H9N2 in mink may drive the virus to adapt mammals; continual surveillance of influenza virus in mink was warranted.

引用

页码：904 / 910

页数：7

共 29 条

[11] CONTACT INFECTION OF MINK WITH 5 SUBTYPES OF AVIAN INFLUENZA-VIRUS - BRIEF REPORT [J].

OKAZAKI, K ;

YANAGAWA, R ;

KIDA, H .

ARCHIVES OF VIROLOGY, 1983, 77 (2-4) :265-269

[12] Avian Influenza H9N2 Seroprevalence among Poultry Workers in Pune, India, 2010 [J].

Pawar, Shailesh D. ;

Tandale, Babasaheb V. ;

Raut, Chandrashekhar G. ;

Parkhi, Saurabh S. ;

Barde, Tanaji D. ;

Gurav, Yogesh K. ;

Kode, Sadhana S. ;

Mishra, Akhilesh C. .

PLOS ONE, 2012, 7 (05)

[13] Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus [J].

Pu, Juan ;

Wang, Shuoguo ;

Yin, Yanbo ;

Zhang, Guozhong ;

Carter, Robert A. ;

Wang, Jinliang ;

Xu, Guanlong ;

Sun, Honglei ;

Wang, Min ;

Wen, Chu ;

Wei, Yandi ;

Wang, Dongdong ;

Zhu, Baoli ;

Lemmon, Gordon ;

Jiao, Yuannian ;

Duan, Susu ;

Wang, Qian ;

Du, Qian ;

Sun, Meng ;

Bao, Jinnan ;

Sun, Yipeng ;

Zhao, Jixun ;

Zhang, Hui ;

Wu, Gang ;

Liu, Jinhua ;

Webster, Robert G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (02) :548-553

[14]

Qi W., 2014, EUROSURVEILLANCE WEE, V19

[15] THE NEIGHBOR-JOINING METHOD - A NEW METHOD FOR RECONSTRUCTING PHYLOGENETIC TREES [J].

SAITOU, N ;

NEI, M .

MOLECULAR BIOLOGY AND EVOLUTION, 1987, 4 (04) :406-425

[16] Characterizations of H4 avian influenza viruses isolated from ducks in live poultry markets and farm in Shanghai [J].

Shi, Ying ;

Cui, Hongrui ;

Wang, Junheng ;

Chi, Qiuyan ;

Li, Xuesong ;

Teng, Qiaoyang ;

Chen, Hongjun ;

Yang, Jianmei ;

Liu, Qinfang ;

Li, Zejun .

SCIENTIFIC REPORTS, 2016, 6

[17] Evidence of avian-like H9N2 influenza A virus among dogs in Guangxi, China [J].

Sun, Xiangxiang ;

Xu, Xiankun ;

Liu, Qi ;

Liang, Danjie ;

Li, Chunying ;

He, Qisong ;

Jiang, Jiaxia ;

Cui, Yueming ;

Li, Jun ;

Zheng, Liefeng ;

Guo, Jiangang ;

Xiong, Yi ;

Yan, Jianhua .

INFECTION GENETICS AND EVOLUTION, 2013, 20 :471-475

[18] Genetic polymorphisms and HPV infection in oral squamous cell carcinomas [J].

Sun, Yan ;

Zhang, Yang ;

Liu, Limei ;

Song, Xicheng ;

Li, Guojun .

CURRENT OPINION IN VIROLOGY, 2015, 14 :1-6

[19] High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses [J].

Sun, Yipeng ;

Qin, Kun ;

Wang, Jingjing ;

Pu, Juan ;

Tang, Qingdong ;

Hu, Yanxin ;

Bi, Yuhai ;

Zhao, Xueli ;

Yang, Hanchun ;

Shu, Yuelong ;

Liu, Jinhua .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (10) :4164-4169

[20] Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008 [J].

Sun, Yipeng ;

Pu, Juan ;

Jiang, Zhanlei ;

Guan, Tao ;

Xia, Yingju ;

Xu, Qi ;

Liu, Linqing ;

Ma, Bo ;

Tian, Fulin ;

Brown, E. G. ;

Liu, Jinhua .

VETERINARY MICROBIOLOGY, 2010, 146 (3-4) :215-225

← 1 2 3 →