Upregulation of Senescent/Exhausted Phenotype of CAR T Cells and Induction of Both Treg and Myeloid Suppressive Cells Correlate with Reduced Response to CAR T Cell Therapy in Relapsed/Refractory B Cell Malignancies

被引：13

作者：

Beider, Katia ^{[1
]}

Besser, Michal J. ^{[2
]}

Schachter, Jacob ^{[2
]}

Grushchenko-Polaq, Ania Hava ^{[1
]}

Voevoda, Valeria ^{[1
]}

Wolf, Idit ^{[1
]}

Ostrovsky, Olga ^{[1
]}

Jacoby, Elad ^{[3
]}

Shimoni, Avichai ^{[1
]}

Nagler, Arnon ^{[4
]}

机构：

[1] Chaim Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Ramat Gan, Israel

[2] Sheba Med Ctr, Ella Lemelbaum Inst Immuno Oncol, Ramat Gan, Israel

[3] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Ramat Gan, Israel

[4] Tel Aviv Univ, Div Hematol & Bone Marrow Transplantat, Chaim Sheba Med Ctr, Ramat Gan, Israel

来源：

关键词：

D O I：

10.1182/blood-2019-128068

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

3234

引用

页数：3